ABSTRACT
Objective To explore the clinical application effect of squamous cell carcinoma antigen (SCC) ,cancer embryo antigen (CEA) and carbohydrate antigen 125(CA125) chemiluminescence combined detection in early diagnosis of lung cancer .Methods The SCC ,CEA and CA125 levels in the patients with early stage lung cancer ,benign lung diseases and healthy subjects undergoing physical examination were detected by using the automatic chemiluminescence immune analyzer .Results The concentrations of three tumor markers in the lung cancer group were significantly higher than those in the benign disease group and control group (P<0 .05);t he concentrations of CEA and CA125 in the adenocarcinoma patients with were significantly higher than those in the patients with squamous cell carcinoma and small cell carcinoma (P<0 .05) .The concentration of SCC in the patients with squamous cell carcinoma was significantly higher than that in the patients with adenocarcinoma and small cell lung cancer (P<0 .05) .The sen-sitivity ,specificity ,positive predictive value and negative predictive value of combined detection of three tumor markers were signifi-cantly better than that of single tumor marker ,and the difference was statistically significant (P<0 .05) .Conclusion The combined detection of SCC ,CEA and CA125 can be used in the early diagnosis of lung cancer and has the promotion value .
ABSTRACT
ObjectiveTo explore the effect of external fixation of damage control operation for treating severe multiple injury patients complicated with open tibia and fibula fractures.MethodsFiftyeight severe multiple injury patients complicated with open tibia and fibula fractures from June 2006 to February 2011 were reviewed.According to the control strategy for tibia and fibula fractures,all patients were divided into two groups:32 patients in observation group were treated with external fixation and 26 patients in control group were treated with calcaneal traction or gypsum external fixation.Wound healing time,fracture healing time,and the incidence rate of acute respiratory distress syndrome (ARDS) and multiorgan dysfunction syndrome (MODS),mortality and wound infection rate within 1 month between two groups were compared.ResultsIn observation group,incidence of ARDS and wound infection rate within 1 month,wound healing time was 6.25％(2/32),31.25％(10/32) and (21.47 ± 6.84) d,respectively,while 24.00％(6/25),64.00％ ( 16/25 ) and (30.26 ± 2.18 ) d in control group,respectively,there were significant differences between two groups(P ＜0.05).The differences of the incidence rate of MODS and mortality within 1 month,fracture healing time of observation group were not statistically significant compared with control group (P ＞ 0.05).ConclusionExternal fixation of damage control operation for treating severe multiple injury patients complicated with open tibia and fibula fractures has the advantages of reducing complication occurrence and improving success rate.